Basic Cyclomen Information

• INN (International Nonproprietary Name): Danazol
• Brand names available in Australia: Cyclomen, Danol
• ATC Code: G03XA01
• Forms & dosages: Capsules available in 50mg and 100mg
• Manufacturers in Australia: Aspen Pharmacare, Teva
• Registration status in Australia: Prescription-only (Rx)
• OTC / Rx classification: Prescription required

Availability & Price Landscape

The accessibility of Cyclomen is primarily through well-known national pharmacy chains such as Chemist Warehouse, Priceline, and TerryWhite. Most of these pharmacy outlets stock Cyclomen capsules in both 50mg and 100mg dosages. Urban settings enjoy robust distribution networks, making Cyclomen easily available for city-dwellers. In contrast, rural areas may encounter inconsistent stock levels, as these locations sometimes struggle with limited supply chains. However, ongoing efforts are aimed at improving access even in less populated regions.

Online Pharmacy Trends in Australia

As e-prescriptions and telehealth gain traction, the landscape of medication access is changing rapidly. Patients increasingly find Cyclomen available online, thanks to the convenience of telehealth consultations. This shift not only broadens accessibility but also enhances patient convenience, allowing individuals to obtain prescriptions without the hurdles of in-person visits. The integration of online pharmacy options means that patients can now order Cyclomen from the comfort of their homes, effectively reducing barriers to access, especially for those living far from major pharmacies.

Price Ranges by Package Size

When it comes to affordability, how Cyclomen is purchased can significantly affect pricing. For patients with a Healthcare Card or those eligible for the Pharmaceutical Benefits Scheme (PBS), the cost can be considerably less. The PBS-subsidised price for Cyclomen typically ranges from $30 to $50 depending on specific formulations. For those purchasing privately, Cyclomen may range higher, leaning towards $70 or more per pack. Notably, it is available in various packaging sizes, predominantly 50mg and 100mg capsules, catering to different patient needs. Understanding these price distinctions can assist patients in making informed choices about their treatment options. In Australia, accessing up-to-date price information through pharmacy websites or direct inquiries can help optimise healthcare decisions.

Dosage & Administration

Standard regimens

Cyclomen, which contains danazol, is primarily prescribed for conditions like endometriosis, fibrocystic breast disease, and hereditary angioedema. The standard dosing schedules vary depending on the indication and patient specifics:

• Endometriosis: The initial dosage is typically 200 mg/day, taken in two divided doses. In more resistant cases, this may be increased up to 800 mg/day. Treatment duration usually spans from 3 to 9 months.
• Fibrocystic breast disease: A daily dosage ranging from 100 to 400 mg is common, administered in divided doses for 3 to 6 months, after which the response is evaluated.
• Hereditary angioedema: Patients are started on 200 mg/day, split into two doses, but this can be adjusted based on the individual's specific needs, with maintenance dosages tapering to 50-100 mg/day.

Adjustments by patient type

Certain patient populations may require dosage adjustments when using Cyclomen:

• Elderly: For older adults, caution is advised since they are at greater risk of experiencing hepatic or cardiovascular side effects. Increased monitoring of liver function is recommended.
• Individuals with chronic conditions: Those with hepatic or renal impairment should use Cyclomen with caution. It is contraindicated in cases of marked hepatic impairment. For mild to moderate impairment, careful monitoring is crucial.

Contraindications & Side Effects

Common

As with any medication, Cyclomen can cause side effects. The most commonly reported ones include:

• Weight gain
• Oily skin and acne
• Menstrual irregularities, including amenorrhea
• Hot flashes and mood swings
• Voice changes due to androgenic effects (hoarseness or deepening)

Australian data shows that while these side effects are generally mild to moderate, some patients experience elevated liver enzymes, minor headaches, or rashes.

Rare but serious

On rare occasions, more severe effects can happen and require close monitoring, particularly in certain populations. Key considerations include:

• Severe hepatic impairment: This is an absolute contraindication for Cyclomen.
• Active thrombosis: Patients with conditions involving thromboembolic disease should not use Cyclomen due to increased clotting risk.
• Individual hypersensitivity to danazol is also a contraindication.

Monitoring is essential for those with a history of thromboembolic events, as the risks may increase.

Comparable Medicines

Alternatives table

Drug (INN)	Brand Names	Notes
Leuprolide	Lupron, Eligard	GnRH agonist, often used for similar indications as Cyclomen in endometriosis.
Goserelin	Zoladex	Similar use cases, primarily in hormone-sensitive conditions.
Medroxyprogesterone	Provera	Potential alternative for hormonal regulation in women.
GnRH antagonists	Relugolix, Elagolix	Newer, oral therapies for managing endometriosis symptoms.

Pros and cons list

Cyclomen offers certain benefits over alternatives, including its efficacy in managing endometriosis. However, it also has drawbacks:

• Pros:
  • Broad therapeutic range (endometriosis, fibrocystic breast disease)
  • Effective in reducing severe symptoms in women
• Cons:
  • Side effects may impact quality of life, particularly androgenic effects.
  • Contradictions in certain populations limit its usability.

Current Research & Trends

Major studies 2022–2025

Recent studies focusing on Cyclomen have emerged, revealing insights into its effectiveness and safety. Notable findings include:

• Research indicates Cyclomen significantly reduces endometriosis-related pain when compared to placebo treatments.
• International studies emphasise the importance of monitoring hepatic function due to observed variations in liver enzymes among users.
• Emerging data suggests potential applications of danazol in treating other hormonal disorders, extending its use beyond initial indications.

These studies not only validate previous efficacy claims but also highlight the need for ongoing monitoring and patient education regarding risks.

Common Patient Questions

Patients often have concerns about taking Cyclomen. Here are some frequently asked questions:

• What side effects should I watch for? Weight gain and hormonal changes are common, but liver function should also be monitored.
• Can it be taken during pregnancy? Cyclomen is contraindicated during pregnancy due to its teratogenic risk.
• How long will I need to take it? Treatment duration varies, with typical courses lasting from 3 to 9 months, depending on the condition being treated.
• What should I do if I miss a dose? Take it as soon as you remember, but never double up if it’s near the next scheduled dose.
• How is Cyclomen stored? Keep it at room temperature and protect it from moisture and light.

Understanding these key aspects helps patients navigate their treatment journey more effectively.

Regulatory Status

TGA approval

The Therapeutic Goods Administration (TGA) has granted regulatory approval for Cyclomen as a prescription medicine in Australia. This system ensures that medications like Cyclomen undergo extensive assessment and adhere to strict safety and efficacy standards before they reach the market. The TGA's ongoing monitoring processes involve regular reviews of safety data and adverse events. Any side effects or issues reported by healthcare professionals and patients alike are closely scrutinised to ensure Cyclomen remains safe for use. Furthermore, any new findings regarding contraindications or side effects can lead to immediate changes in usage guidelines, as safety remains the paramount concern of TGA oversight.

PBS subsidy details

Cyclomen is accessible under the Pharmaceutical Benefits Scheme (PBS) for eligible patients, significantly reducing the financial burden of this medication. Patients diagnosed with specific conditions, such as endometriosis, may qualify for the PBS subsidy. The subsidy can be a game-changer, bringing down the prescribed cost of Cyclomen, which is crucial for those requiring long-term treatment. Eligible Australians can expect to pay a reduced rate compared to the full price, ensuring that necessary treatments are more accessible and affordable.

Visual Recommendations

To effectively communicate important information about Cyclomen, consider creating engaging infographics. Here are some ideas:

• Pricing Structure: Showcase a comparative view of Cyclomen prices across different pharmacy networks, highlighting savings for PBS-eligible patients.
• Availability Map: An accessible map that illustrates where Cyclomen is readily available across Australia, including notable pharmacy chains.
• Usage Guidelines: A visual guide displaying correct dosages and administration schedules, simplifying complex medical recommendations for a broader audience.
• Side Effects Chart: A clear, concise chart that outlines common and rare side effects, assisting patients in recognising important reactions.

Buying & Storage Advice

In-store vs online purchase tips in Australia

Purchasing Cyclomen is feasible both in-store and online, but ensuring safety is vital. Here are simple tips for each method:

• In-Store: Consult with a pharmacist for personalized advice and check for stock availability.
• Online: Always choose reputable online pharmacies that require a prescription, ensuring a safe and legal procurement of Cyclomen.

Regardless of where the product is purchased, a valid prescription is mandatory, and patients should consult healthcare professionals for guidance on appropriate usage.

Storage in Australian household conditions

Preserving the efficacy of Cyclomen requires attention to storage conditions, especially given Australia's diverse climate:

• Temperature: Store Cyclomen at room temperature, ideally between 15°C and 30°C.
• Humidity: Ensure the medication is kept in a dry environment, away from moisture.
• Light Exposure: Protect Cyclomen from direct sunlight to maintain its potency.

Guidelines for Proper Use

Pharmacist guidance in Australia

Pharmacists play a crucial role in assisting patients who are prescribed Cyclomen. They offer vital information regarding dosage, potential interactions with other medications, and expected side effects. This hands-on support can help patients manage their treatment plans effectively. Regular consultations with pharmacists can also ensure adherence to prescribed usage, giving patients confidence in their medications.

Patient safety recommendations

For those using Cyclomen, adhering to safe usage practices is key:

• Follow prescription: Always stick to the prescribed dosage and schedule to avoid complications.
• Monitor for side effects: Be vigilant in recognising any adverse reactions, and report them to a healthcare professional promptly.
• Avoid self-medication: Changes in dosage without professional approval can lead to serious health risks.

By staying informed and keeping open communication with healthcare providers, patients can use Cyclomen safely and effectively.

Delivery Times Across Major Cities

City	Region	Delivery Time
Sydney	New South Wales	5–7 days
Melbourne	Victoria	5–7 days
Brisbane	Queensland	5–7 days
Perth	Western Australia	5–7 days
Adelaide	South Australia	5–7 days
Canberra	Australian Capital Territory	5–7 days
Hobart	Tasmania	5–9 days
Darwin	Northern Territory	5–9 days
Gold Coast	Queensland	5–9 days
Newcastle	New South Wales	5–9 days
Central Coast	New South Wales	5–9 days
Sunshine Coast	Queensland	5–9 days
Coffs Harbour	New South Wales	5–9 days